Liverpool Metropolitan Cathedral was ransacked and vandalised in the early hours of this morning.
Thieves are reported to have broken in through a flat roof near the front entrance of the cathedral, stealing cash and smashing glass images.
It was discovered after an intruder alarm was activated at around 2.45am.
Detective Chief Inspector Phil Mahon told the Liverpool Echo: “I am sure the people of Liverpool will be shocked to discover the Catholic cathedral, such a landmark in the city and a focal point for the community, has been targeted in this way.
“It defies belief that thieves have stolen from a place of worship, causing damage to such a well-valued building that will take time and money to repair.
“I would appeal to anyone who has information to contact us so we can find those responsible.”
Canon Anthony O’Brien, dean of the Metropolitan Cathedral of Christ the King, said: “The whole of the Cathedral community has been left deeply saddened by this needless vandalism and damage.
“Two images in glass, specially made for the cathedral, have been smashed beyond repair and may be impossible to replace. People from throughout the world visit the cathedral and those here this morning have been both shocked and horrified at what has taken place.”
Liverpool Metropolitan Cathedral was built in 1967.